Hypomethylation of CDH3 promoter in colorectal cancer 1 Ectopic expression of P-Cadherin correlates with CDH3 promoter hypomethylation in colorectal cancer and enhanced intestinal crypt fission in mice
نویسندگان
چکیده
Department of Clinical Pharmacology, University of Oxford, Oxford, UK. Digestive Diseases Centre, Leicester Royal Infirmary, University of Leicester, Leicester, UK. Histopathology Unit, Cancer Research UK, London Research Institute, London, UK. Department of Surgery, Royal Infirmary, University of Edinburgh, Edinburgh, UK. Molecular and Population Genetics, Cancer Research UK, London Research Institute, London, UK. Instituto Aragones de Ciencias de la Salud, CIBERehd, Zaragoza, Spain. Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, University of Leicester, Leicester, UK. Bioinformatics and Biostatistics, Cancer Research UK, London Research Institute, London, UK.
منابع مشابه
Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo.
P-cadherin is normally expressed in the basal layer of squamous epithelia and absent from the healthy intestine and colon. We have previously shown it to be expressed in all inflamed, hyperplastic, and dysplastic intestinal and colonic mucosa. This study aimed to better understand the mechanisms controlling the expression of P-cadherin and the biological effects of its ectopic presence in the i...
متن کاملDemethylation of the CDH3 gene is frequently detected in advanced colorectal cancer.
BACKGROUND Recently, it has been proven that the CDH3 promoter was hypomethylated in colonic aberrant foci and colorectal cancer. The hypomethylation was also associated with induction of CDH3 expression in colorectal cancer. These results indicated that epigenetic demethylation of the CDH3 promoter in the human intestine permits its ectopic expression in colorectal cancer. MATERIALS AND METH...
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Inorganic arsenicals are worldwide environmental contaminants that affect molecular characteristics in biological systems and lead to genomic and epigenomic instability as well as epithelial mesenchymal transition (EMT). In this study, we aimed to investigate whether low levels of sodium arsenite (iAsIII) can influence EMT and genomic instability through microsatellite analysis. We have also de...
متن کاملP-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation.
PURPOSE P-cadherin overexpression has been reported in breast carcinomas, where it was associated with proliferative high-grade histological tumors. This study aimed to analyze P-cadherin expression in invasive breast cancer and to correlate it with tumor markers, pathologic features, and patient survival. Another purpose was to evaluate the P-cadherin promoter methylation pattern as the molecu...
متن کاملP-Cadherin (CDH3) is overexpressed in colorectal tumors and has potential as a serum marker for colorectal cancer monitoring
Introduction Placental-Cadherin (CDH3) is a cell adhesion molecule vital to cellular localization and tissue integrity. It is highly expressed in the placenta (PLC)and is overexpressed by many types of cancer. P-cadherin levels in colorectal cancer (CRC) remains poorly characterized. This study's purpose was to determine P-cadherin expression in CRC and normal tissues and to assess plasma CDH3 ...
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